Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. This canonical Notch signaling pathway has been documented to influence T cell development and function. However, the mechanistic details underlying this process remai...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2018
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-17-3535